Episode 2922
Aspartate transaminase
Sun, 2025-May-04 00:09 UTC
Length - 2:06
Direct Link
Welcome to Random Wiki of the Day, your journey through Wikipedia's vast and varied content, one random article at a time.
The random article for Sunday, 4 May 2025, is Aspartate transaminase.
Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase (GOT, SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954. AST catalyzes the reversible transfer of an α-amino group between aspartate and glutamate and, as such, is an important enzyme in amino acid metabolism. AST is found in the liver, heart, skeletal muscle, kidneys, brain, red blood cells and gall bladder. Serum AST level, serum ALT (alanine transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.
The half-life of total AST in the circulation approximates 17 hours and, on average, 87 hours for mitochondrial AST. Aminotransferase is cleared by sinusoidal cells in the liver.
This recording reflects the Wikipedia text as of 00:09 UTC on Sunday, 4 May 2025.
For the full current version of the article, see Aspartate transaminase on Wikipedia.
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