Episode 2269
Thienorphine
Fri, 2023-Jul-21 01:14 UTC
Length - 1:57
Direct Link
Welcome to random Wiki of the Day where we read the summary of a random Wikipedia page every day.
The random article for Friday, 21 July 2023 is Thienorphine.
Thienorphine is a very potent, extremely long-acting, orally-active opioid analgesic with mixed agonist–antagonist properties which was developed by the Beijing Institute of Pharmacology and Toxicology as a potential treatment for opioid dependence. It is a high-affinity, balanced ligand of the μ- (Ki = 0.22 nM), δ- (Ki = 0.69 nM), and κ-opioid receptors (Ki = 0.14 nM), behaving as a partial agonist of the μ- (Emax = 19%–28%) and κ-opioid receptors (Emax = 65–75%) and as an antagonist of the δ-opioid receptor. It also possesses relatively low affinity for the nociceptin receptor (Ki = 36.5 nM), where it acts as an antagonist.
This recording reflects the Wikipedia text as of 01:14 UTC on Friday, 21 July 2023.
For the full current version of the article, see Thienorphine on Wikipedia.
This podcast is produced by Abulsme Productions based on Wikipedia content and is released under a Creative Commons Attribution-ShareAlike License.
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This has been Aditi Standard. Thank you for listening to random Wiki of the Day.
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