Episode 1209
Nonsteroidal estrogen
Tue, 2020-Aug-25 00:51 UTC
Length - 1:52
Direct Link
Welcome to random Wiki of the Day where we read the summary of a random Wikipedia page every day.
The random article for Tuesday, 25 August 2020 is Nonsteroidal estrogen.
A nonsteroidal estrogen is an estrogen with a nonsteroidal chemical structure. The most well-known example is the stilbestrol estrogen diethylstilbestrol (DES). Although nonsteroidal estrogens formerly had an important place in medicine, they have gradually fallen out of favor following the discovery of toxicities associated with high-dose DES starting in the early 1970s, and are now almost never used. On the other hand, virtually all selective estrogen receptor modulators (SERMs) are nonsteroidal, with triphenylethylenes like tamoxifen and clomifene having been derived from DES, and these drugs remain widely used in medicine for the treatment of breast cancer among other indications. In addition to pharmaceutical drugs, many xenoestrogens, including phytoestrogens, mycoestrogens, and synthetic endocrine disruptors like bisphenol A, are nonsteroidal substances with estrogenic activity.
This recording reflects the Wikipedia text as of 00:51 UTC on Tuesday, 25 August 2020.
For the full current version of the article, see Nonsteroidal estrogen on Wikipedia.
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This has been Joanna Neural. Thank you for listening to random Wiki of the Day.
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