Episode 1161
JWH-098
Wed, 2020-Jul-08 01:15 UTC
Length - 1:41
Direct Link
Welcome to random Wiki of the Day where we read the summary of a random Wikipedia page every day.
The random article for Wednesday, 8 July 2020 is JWH-098.
JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around ten fold selective for CB1 over CB2, in JWH-098 this is reversed, and it is around four times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding.
This recording reflects the Wikipedia text as of 01:15 UTC on Wednesday, 8 July 2020.
For the full current version of the article, see JWH-098 on Wikipedia.
This podcast is produced by Abulsme Productions based on Wikipedia content and is released under a Creative Commons Attribution-ShareAlike License.
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This has been Kevin Neural. Thank you for listening to random Wiki of the Day.
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