Episode 2054
Cav2.1
Sun, 2022-Dec-18 01:09 UTC
Length - 1:59
Direct Link
Welcome to random Wiki of the Day where we read the summary of a random Wikipedia page every day.
The random article for Sunday, 18 December 2022 is Cav2.1.
Cav2.1, also called the P/Q voltage-dependent calcium channel, is a calcium channel found mainly in the brain. Specifically, it is found on the presynaptic terminals of neurons in the brain and cerebellum. Cav2.1 plays an important role in controlling the release of neurotransmitters between neurons. It is composed of multiple subunits, including alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit is the pore-forming subunit, meaning that the calcium ions flow through it. Different kinds of calcium channels have different isoforms (versions) of the alpha-1 subunit. Cav2.1 has the alpha-1A subunit, which is encoded by the CACNA1A gene. Mutations in CACNA1A have been associated with various neurologic disorders, including familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6.
This recording reflects the Wikipedia text as of 01:09 UTC on Sunday, 18 December 2022.
For the full current version of the article, see Cav2.1 on Wikipedia.
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This has been Joey Standard. Thank you for listening to random Wiki of the Day.
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