DNA polymerase IV
Mon, 2018-Apr-23 00:32 UTC
Length - 2:05
Welcome to random Wiki of the Day where we read the summary of a random Wikipedia page every day.
The random article for Monday, 23 April 2018 is DNA polymerase IV.
DNA polymerase IV is a prokaryotic polymerase that is involved in mutagenesis. It exhibits no 3′→5′ exonuclease (proofreading) activity and hence is error prone. In E. coli, DNA polymerase IV (Pol 4) is involved in non-targeted mutagenesis. Pol IV is a Family Y polymerase expressed by the dinB gene that is switched on via SOS induction caused by stalled polymerases at the replication fork. During SOS induction, Pol IV production is increased tenfold and one of the functions during this time is to interfere with Pol III holoenzyme processivity. This creates a checkpoint, stops replication, and allows time to repair DNA lesions via the appropriate repair pathway. Another function of Pol IV is to perform translesion synthesis at the stalled replication fork like, for example, bypassing N2-deoxyguanine adducts at a faster rate than transversing undamaged DNA. Cells lacking dinB gene have a higher rate of mutagenesis caused by DNA damaging agents.
This recording reflects the Wikipedia text as of 00:32 UTC on Monday, 23 April 2018.
For the full current version of the article, go to http://en.wikipedia.org/wiki/DNA_polymerase_IV.
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