Episode 1592
Leukocidin
Sun, 2021-Sep-12 00:04 UTC
Length - 2:23
Direct Link
Welcome to random Wiki of the Day where we read the summary of a random Wikipedia page every day.
The random article for Sunday, 12 September 2021 is Leukocidin.
A leukocidin is a type of cytotoxin created by some types of bacteria (Staphylococcus). It is a type of pore-forming toxin. The model for pore formation is step-wise. First, the cytotoxin’s “S” subunit recognizes specific protein-containing receptors, or an integrin on the host cell’s surface. The S subunit then recruits a second, “F” subunit, and the two subunits dimerize on the surface of the host’s cell. After dimerization, oligomerization occurs. Finally, the oligomers, consisting of alternating S and F subunits, undergo a significant structural change and form a beta-barrel, that pierces through the host cell’s lipid bilayer. Leukocidins get their names by killing ("-cide") leukocytes. Leukocidins target phagocytes, natural killer cells, dendritic cells, and T lymphocytes and therefore targets both, innate and adaptive immune responses. Leukocidins fall into the category of bacterial invasin. Invasins are enzymatic secretions that help bacteria invade the host tissue to which they are attached. Although similar to exotoxins, invasins are different in two respects: they work through much less specific mechanisms than exotoxins, and their actions are generally more localized.
One type is Panton-Valentine leukocidin.
This recording reflects the Wikipedia text as of 00:04 UTC on Sunday, 12 September 2021.
For the full current version of the article, see Leukocidin on Wikipedia.
This podcast is produced by Abulsme Productions based on Wikipedia content and is released under a Creative Commons Attribution-ShareAlike License.
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This has been Salli Neural. Thank you for listening to random Wiki of the Day.
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